Lotrisone

General description:

Lotrisone cream is used to cure inflamed fungal skin infections such as ringworm, jock itch and athlete’s foot. It is a combination of 2 medications: clotrimazole and betamethasone. Clotrimazole is an azole antifungal medication that treats fungal infections by preventing the growth of fungi. Betamthasone is a corticosteroid that reduces swelling, itching and redness. 

This medication is not suitable for people younger than 17 years of age.

Store this medication at 20 to 25°C.

Pharmacokinetics: 

Once the cream is absorbed into the skin, corticosteroids bind to plasma proteins. Corticosteroids are then metabolized in liver and excreted by the kidneys. Clotrimazole inhibits 14-alpha-demethylation of lanosterol in fungi by attaching to cytochrome p-450 enzymes. This results in accumulation of methyl sterols that are essential for cytoplasmic membrane of fungi. Those methyl sterols in turn can affect the electron transportation, thus inhibiting the fungal growth.

How to use: 

Rinse your hands before applying the cream. Apply a sufficient amount of cream and rub it gently onto the affected area. This procedure needs to be done twice daily.  DO NOT cover skin with a bandage or any other tight clothing after applying the cream. Before dressing, allow your skin to dry and absorb the cream.

For treating ringworm or jock itch, use the cream for 2 weeks. For treating athlete’s foot, apply Lotrisone for 4 weeks. DO NOT use more than 45 grams of cream per week, unless consulted with doctor.

Side effects:

● Dry skin

● Burning 

● Tingling 

● Weight loss

● Tiredness 

● Irritability 

● Extreme hair growth 

● Skin thinning 

● Rash

● Swelling 

It is very rare to experience a serious allergic reaction to this drug. However, contact you doctor straight away if you notice any allergic symptoms like rash, itching, redness.

Precautions:

● DO NOT apply the cream in the eyes, mouth, nose, underarms or vagina

● DO NOT use longer or shorter than prescribed

● Consult your doctor if you need to use the medication during pregnancy 

● DO NOT apply the cream on dry, chapped, sunburned or irritated skin 

● It is not recommended to use Lotrisone for diaper dermatitis